SCREENING OF ANGIOTENSIN I-CONVERTING ENZYME INHIBITION OF THAI INDIGENOUS VEGETABLES
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Abstract
Nowadays, a trend which consuming foods preventing diseases becomes more popular in Thai people. Hypertension is one of chronic diseases in which can be prevented using this strategy. Thus, the researchers aim to investigate Thai indigenous vegetables which possess antihypertensive activity. In this article, angiotensin I-converting enzyme inhibition (ACEi) model coupling with HPLC analysis was used as a method for screening of vegetables possessed this activity. The vegetable extracts were obtained using sonication in ethanol. The ACEi activity was determined calculating from the present of hippuric acid. While 0.1 mg/ml captopril showed 100 percent ACEi activity, it was found that Glochidion perakense and Litsea sp. at the concentration 1 mg/ml showed high ACEi activity in which the values were 90.3 and 92.1 percent, respectively. To prevent hypertension, it is a possibility to include both vegetables into meal in combination with lifestyle modification.
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