CYTOTOXIC ACTIVITY OF RACEMOSAL AND DEMETHYLRACEMOSAL FROM BAUHINIA MALABARICA AGAINST HUMAN COLON CANCER COLO 205 CELLS

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Published: Oct 5, 2023

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Suchada Jongrungruangchok
Department of Pharmaceutical chemistry, Faculty of Pharmacy, RangsitUniversity, PathumThani 12000, Thailand
Nalinee Pradubyat
Department of Pharmacology, Faculty of Pharmacy, RangsitUniversity,PathumThani 12000, Thailand
Thanapat Songsak
Department of Pharmacognosy, Faculty of Pharmacy, RangsitUniversity,PathumThani 12000, Thailand
Supakit Wongwiwatthananukit
Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI

Abstract

Bauhinia malabarica Roxb.(Caesalpiniaceae) has been used in Thai traditional medicine for analgesic, antiinflammatory, antineoplastic, antidiabetic, antiulcers, antileprosy, antibronchitis, antiamoebic, antidysenteric, and hypocholesterolemic. Racemosal and demethylracemosal were isolated from the root of B. malabarica and were identified by NMR spectroscopy and mass spectroscopy. MTT assay showed that racemosal and demethylracemosal significantly exhibited cytotoxic activity against human colon cancer colo 205 cells exhibiting the IC50 values of 6.16 and 6.45 μM, respectively.

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1.
Jongrungruangchok S, Pradubyat N, Songsak T, Wongwiwatthananukit S. CYTOTOXIC ACTIVITY OF RACEMOSAL AND DEMETHYLRACEMOSAL FROM BAUHINIA MALABARICA AGAINST HUMAN COLON CANCER COLO 205 CELLS. Interprof J Health Sci [Internet]. 2023 Oct. 5 [cited 2024 Sep. 17];14(1):93-102. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/137
Issue
Vol. 14 No. 1 (2016): January - June
Section
Research Articles
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