CYTOTOXIC ACTIVITY OF 4H–CHROMENES ON COLO 205 HUMAN COLON ADENOCARCINOMA CELL LINE

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Published: Oct 5, 2023
Keywords:
4H-chromenes cytotoxic activity human colon adenocarcinoma cell line (COLO 205)

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Suchada Jongrungruangchok
Department of Pharmaceutical chemistry, Faculty of Pharmacy, Rangsit University, PathumThani 12000, Thailand
Nalinee Pradubyat
Department of Pharmacology, Faculty of Pharmacy, Rangsit University,PathumThani 12000, Thailand
Thanapat Songsak
Department of Pharmacognosy, Faculty of Pharmacy, Rangsit University,PathumThani 12000, Thailand
Supakit Wongwiwatthananukit
Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, HI

Abstract

H-chromenes are synthetic benzopyran derivatives which have various pharmacological activities. This study aimed to investigate and compare the cytotoxic activity of three selected 4H-chromenes (compound I, II, and III) against human colon adenocarcinoma cell line (COLO 205) using MTT assay. Cells were treated with increasing concentrations of compound I, II, and III from 20 to 200 µM and incubated for 24 hours. The results were presented as the percentage of viable cells compared to control (untreated cells). At the concentration from 20 to 200 µM, compound I, II and III showed a significant decline in % mean viability on COLO 205 cells from 85.63% to 2.01%, 89.18% to 1.31%, and 68.03 % to 7.42%, respectively. Compound I, II and III significantly exhibited cytotoxic activity against COLO 205 cells with IC50 of  26, 30, and 150 μM, respectively. 

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How to Cite
1.
Jongrungruangchok S, Pradubyat N, Songsak T, Wongwiwatthananukit S. CYTOTOXIC ACTIVITY OF 4H–CHROMENES ON COLO 205 HUMAN COLON ADENOCARCINOMA CELL LINE. Interprof J Health Sci [Internet]. 2023 Oct. 5 [cited 2024 Dec. 22];14(2):27-32. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/146
Issue
Vol. 14 No. 2 (2016): July - December
Section
Research Articles
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