ANGIOTENSIN I-CONVERTING ENZYME INHIBITOR ACTIVITY OF SOME MEDICINAL PLANTS LISTED IN TRADITIONAL THAI MEDICINE
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Abstract
The ethanolic extracts of selected medicinal plants were screened for angiotensin I-converting enzyme (ACEi) inhibitor activity. The plants comprised of four Apiaceae (Cuminum cyminum, Anethum graveolens, Foeniculum vulgare, Ligusticum sinense), one Apocynaceae (Dischidia major), two Combretaceae (Terminalia berllirica, Terminalia chebula), one Euphorbiaceae (Euphorbia antiquorum), two Calophyllaceae (Mammea siamensis, Mesue ferrea), two Fabaceae (Senna garrettiana, Albizia myriophylla), one Oleaceae (Jasminum sambac), one Malvaceae (Abroma augusta) and one Sapotaceae (Mimusops elengi). Reduction of hippuric acid, a product of substrate-ACE reaction, was determined using HPLC-UV technique. From the result, the ethanolic extracts of M. siamensis flower and S. garrettiana heartwood at the concentration 1 mg/ml showed high ACE inhibitor activity at 97.5 and 92.2 percent, respectively. This finding may supported that M. siamensis and S. garrettiana possessed ACE inhibitor compounds which either can be utilized as anti-hypertensive drugs, or as markers for quality control of traditional Thai medicine.
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References
Aekplakorn W, Sangthonh R et al. 2012. Changes in prevalence, awareness, treatment and control of hypertension in Thai population, 2004-2009: Thai National Health Examination Survey III-IV. J Hypertens. 30(9):1734-1742.
Ahnfelt RI. 1991. Enzyme inhibitor as drugs. In: Krogsgaard LP, Bundgaard H, editors. A textbook of drug design and development. Switzerland: Harvood Academic Publishers, pp. 302-307.
Chuchote C, Pathompak P, Charoonratana T. 2015. Screening of angiotensin I-converting enzyme inhibition of Thai indigenous vegetables. BHST. 13(1): 38-42.
Gunasekera SP, Ramachandran S, Selliah S et al. 1975. Perkin Trans 1. J Chem Soc. 2477.
Hata K, Baba K, Kozawa M. 1978. Chemical studies on the heartwood of Cassia garrettiana Craib. anthraquinones including cassialoin, and new anthrone C-glycoside. Chem Pharm Bull. 26(12): 3792-3797.
Hyang SK, Lee H, Kang SS et al. 2009. Inhibitory activity of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme. Phytother. Res. 23: 178-184.
Inamori Y, Kubo M, Kato Y, Yasuda M et al.1984. The coronary vasodilatory and hypotensive effects of 3, 3', 4, 5'-tetrahydroxystilbene and its derivatives. Yakugaku Zasshi. 104 (7): 819-821.
Israili ZH, Hall WD. 1992. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Ann Intern Med. 117(3): 234-242.
Kaweetripob W, Mahidol C, Prawat H et al. 2000. Chemical Investigation of Mammea siamensis. Pharm Bio. 38(1): 55-57.
Mittal BV, Singh AK. 2010. Hypertension in the developing world: challenges and oppurtunities. Am J Kidney Dis. 55(3): 590-598.
Ngo NTN, Nguyen VT, Vo HV et al. 2010. Cytotoxic Coumarins from the Bark of Mammea siamensis. Chem. Pharm. Bull: 58(11): 1487-1491.
Oparil MD, Zaman MA, Calhoun DA. 2003. Pathogenesis of hypertension. Ann Intern Med. 139: 761-776.
Puavilai W, Laorugpongse D. 2005. Hypertension at Ampur Ban Paew and some risk factors of hypertension. Bull Dept Med Serv. 25: 116-123.
Subhadhirasakul S, Pechpongs P. 2005. A terpenoid and steroids from the flowers of Mammea siamensis. J Sci Technol. 27(2): 555-561.
Tewtrakul S, Suhadhirasakul S, Rattanasuwan P et al. 2007. HIV-protease inhitory substances from C. garrettiana. J Sci Technol. 29(1): 145-149.
Wongwattananukul N, Chansakaow S, Chaiyasut C et al. 2005. Antioxidant activity of Thai aromatic plants and spicies. 31st Congress on Science and Technology of Thailand at Suranaree University of Technology. 18-20 October.
Wu J, Aluko RE, Muir AD. 2002. Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions. J. Chromatogr. A. 950, 125-130.