Global Research Trends in Artificial Intelligence-Driven Conductive Bioinks for Wound Healing: A Bibliometric Analysis (2021–2025)

Main Article Content

Meka Deesongkram
Kreetha Phupardrae
Keerattaya Homthong
Parinda Thussamee
Janyamon Tupila
Jutathip Chumjom

Abstract

Artificial intelligence (AI), conductive bioinks, and advanced wound healing technologies are among the fastest-growing areas at the intersection of regenerative medicine and tissue engineering. This study mapped global research trends in AI-enabled conductive bioinks for wound healing from 2021 to 2025, examining collaboration networks, thematic development, and influential publications. Bibliometric analysis was performed on data retrieved from the Dimensions database, using Bibliometrix and VOSviewer for statistical and visual analyses. Annual scientific output showed a clear upward trajectory, reaching its highest level in 2025, based on records available up to the search date of January 15, 2026. China, India, and the United States led in publication volume, while the United States stood out for the breadth and strength of its international collaboration networks. Keyword co-occurrence mapping revealed three dominant thematic clusters centered on hydrogels, tissue engineering, and 3D printing with polymer science. “Skin” and “3D bioprinting” had the highest domain-specific relevance scores, reflecting a growing focus on skin regeneration and smart wound care. Highly cited publications addressed advanced bioprinting, conductive biomaterials, smart wound dressings, wearable biosensors, and AI-assisted regenerative strategies. Overall, the findings highlight a meaningful convergence of AI, biomaterials science, and wound healing research, with momentum building around intelligent material design, real-time wound monitoring, and precision medicine approaches. This analysis offers a structured view of the field’s intellectual development and serves as a useful reference for researchers and innovators working on next-generation wound care solutions.

Article Details

How to Cite
1.
Deesongkram M, Phupardrae K, Homthong K, Thussamee P, Tupila J, Chumjom J. Global Research Trends in Artificial Intelligence-Driven Conductive Bioinks for Wound Healing: A Bibliometric Analysis (2021–2025). Interprof J Health Sci [Internet]. 2026 Nov. 10 [cited 2026 Nov. 13];24(2):IJHS-1582. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/1582
Section
Research Articles

References

1. Arif ZU, Khalid MY, Hossain M. 3D bioprinting of conductive hydrogel scaffolds: a review on material selection and tissue engineering applications. Int J Biol Macromol. 2024;258:128901. doi:10.1016/j.ijbiomac.2023.128901.

2. Ramakrishna S, Ashammakhi N. Artificial intelligence and machine learning integration in 3D bioprinting of smart biomaterials. Adv Mater. 2023;35(12):2201405. doi:10.1002/adma.202201405.

3. Bioactive Materials [Internet]. Amsterdam: Elsevier; 2024 [cited 2026 Nov 9]. Available from: https://www.sciencedirect.com/journal/bioactive-materials

4. Bioprinting [Internet]. Amsterdam: Elsevier; 2025 [cited 2026 Nov 9]. Available from: https://www.journals.elsevier.com/bioprinting

5. Chemical Engineering Journal [Internet]. Amsterdam: Elsevier; 2024 [cited 2026 Nov 9]. Available from: https://www.sciencedirect.com/journal/chemical-engineering-journal

6. Advanced Materials [Internet]. Hoboken (NJ): Wiley; 2025 [cited 2026 Nov 9]. Available from: https://onlinelibrary.wiley.com/journal/15214095

7. Gels [Internet]. Basel: MDPI; 2024 [cited 2026 Nov 9]. Available from: https://www.mdpi.com/journal/gels

8. Polymers [Internet]. Basel: MDPI; 2024 [cited 2026 Nov 9]. Available from: https://www.mdpi.com/journal/polymers

9. Chemical Reviews [Internet]. Washington (DC): American Chemical Society; 2023 [cited 2026 Nov 9]. Available from: https://pubs.acs.org/journal/chreay

10. Aria M, Cuccurullo C. bibliometrix: an R-tool for comprehensive science mapping analysis. J Informetr. 2017;11(4):959-75. doi:10.1016/j.joi.2017.08.007.

11. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523-38. doi:10.1007/s11192-010-0146-3.

12. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71.

13. Digital Science. Dimensions [Internet]. London: Digital Science; [cited 2026 Nov 9]. Available from: https://www.dimensions.ai/

14. Saadi MASR, Maguire A, Pottackal NT, Thakur SH, Ikram MM, Hart AJ, et al. Direct ink writing: a 3D printing technology for diverse materials. Adv Mater. 2022;34(28):2108855. doi:10.1002/adma.202108855.

15. Tang L, Wang L, Yang X, Feng Y, Li Y, Feng W. Poly(N-isopropylacrylamide)-based smart hydrogels: design, properties and applications. Prog Mater Sci. 2021;115:100702. doi:10.1016/j.pmatsci.2020.100702.

16. Farahani M, Shafiee A. Wound healing: from passive to smart dressings. Adv Healthc Mater. 2021;10(3):2000475. doi:10.1002/adhm.202000475.

17. Hu X, Xu W, Ren Y, Wang Z, He X, Huang R, et al. Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2023;8:245. doi:10.1038/s41392-023-01477-6.

18. Mohanty AK, Wu F, Mincheva R, Hakkarainen M, Raquez JM, Mielewski DF, et al. Sustainable polymers. Nat Rev Methods Primers. 2022;2:1-31. doi:10.1038/s43586-022-00124-8.

19. Ji D, Lin Y, Guo X, Ramasubramanian B, Wang R, Radacsi N, et al. Electrospinning of nanofibres. Nat Rev Methods Primers. 2024;4:1-30. doi:10.1038/s43586-023-00278-z.

20. Min J, Tu J, Xu C, Lukas H, Shin S, Yang Y, et al. Skin-interfaced wearable sweat sensors for precision medicine. Chem Rev. 2023;123(9):5049-138. doi:10.1021/acs.chemrev.2c00823.

21. Liang Y, Liang Y, Zhang H, Guo B. Antibacterial biomaterials for skin wound dressing. Asian J Pharm Sci. 2022;17(3):353-84. doi:10.1016/j.ajps.2022.01.001.

22. Liu S, Yu JM, Gan YC, Qiu XZ, Gao ZC, Wang H, et al. Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications. Mil Med Res. 2023;10(1):1-30. doi:10.1186/s40779-023-00448-w.

23. Zhao Z, Wang Z, Li G, Cai Z, Wu J, Wang L, et al. Injectable microfluidic hydrogel microspheres for cell and drug delivery. Adv Funct Mater. 2021;31(45):2103339. doi:10.1002/adfm.202103339.

24. Elnemr M, Zheng L, Butt H. A comparative bibliometric analysis of artificial intelligence in 3D hydrogel printing: insights from Scopus and Web of Science (2015-2025). ACS Omega. 2025;10(36):40726-39. doi:10.1021/acsomega.5c04479.

25. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi:10.1016/j.diabres.2021.109119.

26. Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367-75. doi:10.1056/NEJMra1615439.

27. Herzog C, Hook D, Konkiel S. Dimensions: bringing down barriers between scientometricians and data. Quant Sci Stud. 2020;1(1):387-95. doi:10.1162/qss_a_00020.

28. Piwowar H, Priem J, Larivière V, Alperin JP, Matthias L, Norlander B, et al. The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles. PeerJ. 2018;6:e4375. doi:10.7717/peerj.4375.

29. Sun J, Yao K, An J, Jing L, Huang K, Huang D. Machine learning and 3D bioprinting. Int J Bioprint. 2023;9(4):717. doi:10.18063/ijb.717.

30. Wagner CS, Park HW, Leydesdorff L. The continuing growth of global cooperation networks in research: a conundrum for national governments. PLoS One. 2015;10(7):e0131816. doi:10.1371/journal.pone.0131816.

31. International Journal of Molecular Sciences [Internet]. Basel: MDPI; 2024 [cited 2026 Nov 9]. Available from: https://www.mdpi.com/journal/ijms

32. Visser M, van Eck NJ, Waltman L. Large-scale comparison of bibliographic data sources: Scopus, Web of Science, Dimensions, Crossref, and Microsoft Academic. Quant Sci Stud. 2021;2(1):20-41. doi:10.1162/qss_a_00112.