PREPARATION AND CHARACTERIZATION OF POLYVINYL ALCOHOL – GRAFT – LACTIC ACID HYDROGEL FILMS
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Abstract
Hydrogel films are thin polymer films which become extremely hydrated after absorbing water or biological fluid into their formation. Polyvinyl alcohol (PVA) is a water soluble synthetic polymer. It has many advantages such as good chemical stability, high hydrophilicity, biocompatibility, and low toxicity with controlled-release drug delivery systems. The aim of this work was to prepare PVA-graft-Lactic acid (PVA-g-LA) hydrogel films by the eco-friendly technique and then characterize by Attenuated total reflectance – Fourier transform infrared spectroscopy (ATR–FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). ATR-FTIR and XRD showed that the PVA-g-LA hydrogel films were a compatible film and a semi-crystalline phase. When they were immersed in distilled water, the PVA-g-LA hydrogel films had high swelling absorption, under SEM cross-section photography. In some cases, propranolol hydrochloride was mixed in selected hydrogel film formulation. The PVA-g-LA hydrogel films had good swelling properties. In conclusion, PVA-g-LA hydrogel films had been prepared by the eco-friendly technique possibly serves as a material for pharmaceutical applications.
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