ANTIMICROBIAL ACTIVITY OF CORONARIN D AGAINST STAPHYLOCOCCUS AUREUS AND ITS SYNERGISTIC POTENTIAL WITH ANTIBIOTICS
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Abstract
Staphylococcus aureus causes various infections in humans such as food poisoning, skin and soft tissue infection, and sepsis. New effective drugs are needed to control S. aureus associated infections due to the emergence and rapid antibiotic resistance. In the present study, the antibacterial activity of Coronarin D, the main compound in Hedichium coronarium, was investigated. Antibacterial activity of coronarin D was tested against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) strains by broth dilution method. Synergistic effects were also determined with a combination of coronarin D and 5 other antibacterial agents. It was found that the MIC and MBC of coronarin D against both MSSA and MRSA were 15.6-50 μg/mL and 50-100 μg/mL, respectively. In addition, the combination of coronarin D and some antibiotics showed more potent antibacterial activity against MSSA and MRSA than antibiotics or coronarin D alone. The best antibacterial activity was seen in the combination of coronarin D-penicillin G at FICI value of 0.25 against MSSA and coronarin D-polymyxin B at FICI value of 0.25 against MRSA. These results showed that coronarin D had antibacterial activity against S. aureus and showed the synergistic effect with certain antibiotics.
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