PON1 L55M GENE POLYMORPHISM AND SERUM PON1 LEVEL IN THAI RICE FARMERS EXPOSED ORGANOPHOSPHATE

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Published: Dec 28, 2022
Keywords:
Paraoxinase1 Organophosphate PON1 L55M PON1 enzyme level

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Wanida Pongstaporn
Pathobiology unit, Department of Medical Sciences, Faculty of Science, Rangsit University. Pathumthani 12000,Thailand
Kanyanan Kritsiriwuthinan
Faculty of Medical Technology, Rangsit University, Pathumthani 12000 Thailand
Yuttana Sudjaroen
Department of Applied Sciences, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Thailand

Abstract

Paraoxinase 1 (PON1) involves in the detoxification of organophosphate compounds.  Polymorphisms of the PON1 gene are responsible for variation in the expression and catalytic activity of PON1. This paper aims to investigate PON1 L55M genotypes in Thai rice farmer who exposed organophosphate. Moreover, PON1 enzyme level was compared between Thai rice farmer whose exposed organophosphate and control subjects. This study revealed that the wild type of PON1 L55M is the majority of agricultural worker who exposed organophosphate (48 out of 50 cases) and serum PON1 level is statistically higher in agricultural worker who exposed organophosphate than in control subjects (p=0.04)

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1.
Pongstaporn W, Kritsiriwuthinan K, Sudjaroen Y. PON1 L55M GENE POLYMORPHISM AND SERUM PON1 LEVEL IN THAI RICE FARMERS EXPOSED ORGANOPHOSPHATE. Interprof J Health Sci [Internet]. 2022 Dec. 28 [cited 2024 Dec. 4];20(1-2):36-42. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/53
Issue
Vol. 20 No. 1-2 (2022): January - December
Section
Research Articles
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