ROLE OF PATIENT-REPORTED OUTCOME MEASURES (PROMs) IN SYSTEMIC LUPUS ERYTHEMATOSUS: A SYSTEMATIC REVIEW
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Abstract
Patient-reported outcomes (PROs) throughout care with individual patients present a critical function in the overall clinical decision-making, which leads to the optimization of the therapeutic plan for Systemic Lupus Erythematosus (SLE) patients. The current study seeks to identify and accurately evaluate all studies appraising patient-reported Health-Related Quality of Life (HRQoL) in patients with SLE. A systematic literature review was performed through SCOPUS database up to January 2021. All potential materials and relevant PROMs were summarized for non-validation studies and perform a methodological quality assessment of identified SLE-specific PROMs studies utilizing the Consensus-based Standards for the selection of health Measurement INstruments (COSMIN). Thirty articles were included in the shortlist to assess PROMs relevant from 3,946 studies initially identified, of which seven materials were used for validation studies focusing on SLE-specific PROMs. High bias (83%) was evident among generic instruments indicating low confidence that the results represent the actual treatment effect. For the validation studies using COSMIN analysis, the reliability of material was determined by the lowest score of all quality items for each criterion of measurement. The systematic review performed is unlikely to determine specific issues concerning the quality of life of the patient due to lack of evidence of its clinimetric importance due to inconsistent study design and PRO reporting in studies. However, studying SLE-specific PROMs has a favorable impact on patients and clinicians concerning its HRQOL, which can further be improved by future researchers when sufficient clinical data and investigations are conducted.
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