APPLICATION OF POLYVINYLPYRROLIDONE K30 AND CHITOSAN AS CO-BINDERS IN PREPARING FUROSEMIDE TABLET BY WET GRANULATION METHOD

Abstract

Furosemide tablets were prepared by wet granulation using polyvinylpyrrolidone K 30 (PVP) alone, as single binder, and PVP with chitosan (CS), as co-binders. Spray-dried rice starch (Era-Tab®) and croscarmellose sodium (Ac-Di-Sol®) were employed as tablet diluent and disintegrant, respectively. The prepared tablets were tested for tablet physical properties, disintegration and dissolution. The effects of PVP, CS and Ac-Di-Sol® contents on tablet friability, disintegration time and dissolution were studied using a two-level full factorial experimental design. The tested properties of furosemide tablets prepared by using the single binder were compared to those prepared by using the co-binders. The usage of co-binders, PVP and CS, was found to significantly decrease the tablet friability without considerable change in disintegration time. The furosemide tablet of good physical properties and fast drug dissolution was prepared by using low content of Ac-Di-Sol® and optimum amounts of the co-binders, PVP and CS. Inclusion of a surfactant, sodium lauryl sulfate (SLS), in the furosemide tablets did not improve the tablet dissolution. No significant change in tablet dissolution profile was observed when sodium starch glycolate (Explotab®) was used as disintegrant, instead of Ac-Di-Sol®, in the furosemide tablets prepared by using co-binders. However, the usage of proper content of SLS in the furosemide tablet formulation consisting of Explotab® was found to provide the tablet of improved dissolution.