SWELLING – DESWELLING CHARACTERIZATION OF MODIFIED POLY VINYL ALCOHOL-GRAFT-LACTIC ACID HYDROGELS – BASED ON ECO-FRIENDLY SYNTHESIS METHOD

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Published: Oct 5, 2023
Keywords:
Eco-friendly synthesis method Modified PVA-g-LA hydrogels Swelling-deswelling behavior

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Jirapornchai Suksaeree
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Pathum Thani, Thailand
Chitradee Luprasong
Sun Herb Thai Chinese Manufacturing Plant, Faculty of Pharmacy, Rangsit University, Pathum Thani, Thailand
Laksana Charoenchai
Sino-Thai Traditional Medicine Research Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani 12000, Thailand
Chaowalit Monton
ino-Thai Traditional Medicine Research Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani 12000, Thailand
Wiwat Pichayakorn
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand

Abstract

The eco-friendly synthesis method is the one choice to reduce and eliminate the usage of hazardous substances based on the principle that it uses nontoxic chemicals, non-environmentally benign solvents, and renewable materials. Therefore, the aim of this study was to study the effect of curing temperature and curing time of modified poly vinyl alcohol-graft-lactic acid (PVA-g-LA) hydrogels. The ratio of PVA and LA was 1:1.5 which prepared in aqueous solutions without initiator and catalyst. Then, it was cured at 100 or 120ºC for 120, 150, or 180 min. After that, it was studied the swelling-deswelling behavior in distilled water and acetone to calculate the ratio of the water absorption amount and the ratio of water retention. The finally, they were measured the ratio of moisture content per dry weight by moisture analyzer. We found the curing temperature and curing time study of modified PVA-g-LA hydrogels directly affected to only the swelling-deswelling behavior but not effect on moisture content in their hydrogels. Therefore, we successfully prepared the modified PVA-g-LA hydrogels by eco-friendly synthesis method, and this modified PVA-g-LA hydrogels might be applied for medical and pharmaceutical device for control drug release in the future study.

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1.
Suksaeree J, Luprasong C, Charoenchai L, Monton C, Pichayakorn W. SWELLING – DESWELLING CHARACTERIZATION OF MODIFIED POLY VINYL ALCOHOL-GRAFT-LACTIC ACID HYDROGELS – BASED ON ECO-FRIENDLY SYNTHESIS METHOD. Interprof J Health Sci [Internet]. 2023 Oct. 5 [cited 2024 Dec. 22];12(2):7-12. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/97
Issue
Vol. 12 No. 2 (2014): July - December
Section
Research Articles
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