DISSOLUTION PROFILE OF A TRADITIONAL THAI ANTIHYPERTENSIVE HERBAL RECIPE IN VARIOUS PREPARATIONS

Main Article Content

Arthimond Vutthipong
Worawan Saingam
Tanate Panrat
Tossaton Charoonratana

Abstract

A dissolution test was developed for a traditional Thai antihypertensive herbal recipe (TTAH) in various preparations. Three different formulations, such as pill, tablet, and capsule, were prepared and evaluated for their release profile in which piperine was chosen as a marker in dissolution study. The test was performed using paddle method with 50 rpm and dissolution medium composed of 0.2 M phosphate buffer pH 7.4. The sampling times were 5, 10, 15, 30, and 60 min. Liquid chromatography mass spectrometry (LC-MS) was used as a tool to determine amount of piperine. Different piperine release profiles were achieved and it was found that the reported method in this article was suitable for dissolution study only in capsule and tablet preparations.

Article Details

How to Cite
1.
Vutthipong A, Saingam W, Panrat T, Charoonratana T. DISSOLUTION PROFILE OF A TRADITIONAL THAI ANTIHYPERTENSIVE HERBAL RECIPE IN VARIOUS PREPARATIONS . Interprof J Health Sci [Internet]. 2023 Oct. 5 [cited 2024 Dec. 6];12(2):20-4. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/99
Section
Research Articles

References

Charoonratana T, Songsak T, Monton C, Saingam W, Bunluepuech K, Suksaeree J, et al. 2014a. Quantitative analysis and formulation development of a traditional Thai antihypertensive herbal recipe. Phytochem. Rev. ; 13(2):511-524.

Charoonratana T, Bunluepuech K, Chusut T, Suksaeree J, Songsak T. 2014b. Development and validation of LC-MS method for quantitative analysis of a traditional Thai antihypertensive herbal recipe. Int. J. Pharm. Sci. ; 6(8):259-262.

Kortejarvi H, Malkki J, Marvola M, Urtti A, Yliperttula M, Pajunen P. 2006. Level A in vitro-in vivo correlation (IVIVC) model with Bayesian approach to formulation series. J. Pharm. Sci. ; 95(7):1595-1605.

The Thai Herbal Pharmacopoeia Committee. 2011. Supplement to Thai Herbal Pharmacopoeia 2011. Bangkok: Prachachon.

The United State Pharmacopeial Convention. 1999. The United State Pharmacopeia 24/The National Formulary 19. Maryland: United Book Press.

TDR. Operation guidance: Information needed to support clinical trials of herbal products, 2005 [cited 2014 August 29]; Available from: http://www.who.int/tdr/publications/tdr-research-publications/operational-guidance/en.

Vutthipong A, Monton C, Saingam W, Bunluepuech K, Charoonratana T. 2014. Evaluation of physicochemical properties of a traditional Thai antihypertensive herbal recipe in various preparations. Int. J. Pharm. Sci. ; 6(8):479-482.

WHO. WHO traditional medicine strategy 2014-2023, 2013 [cited 2014 August 29]; Available from: http://www.who.int/medicines/publications/traditional/trm_strategy14_23/en.