DISSOLUTION PROFILE OF A TRADITIONAL THAI ANTIHYPERTENSIVE HERBAL RECIPE IN VARIOUS PREPARATIONS

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Published: Oct 5, 2023
Keywords:
Dissolution Paddle method LC-MS TTAH Piperine

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Arthimond Vutthipong
Department of Pharmacognosy, Faculty of Pharmacy, Rangsit University, Pathum Thani, Thailand, 12000
Worawan Saingam
Sino-Thai Traditional Medicine Research Center, Faculty of Pharmacy, Rangsit University, Pathum Thani, Thailand, 12000
Tanate Panrat
Prince of Songkla University International College, Prince of Songkla University, Hatyai, Songkhla, Thailand, 90110
Tossaton Charoonratana
Department of Pharmacognosy, Faculty of Pharmacy, Rangsit University, Pathum Thani, Thailand, 12000

Abstract

A dissolution test was developed for a traditional Thai antihypertensive herbal recipe (TTAH) in various preparations. Three different formulations, such as pill, tablet, and capsule, were prepared and evaluated for their release profile in which piperine was chosen as a marker in dissolution study. The test was performed using paddle method with 50 rpm and dissolution medium composed of 0.2 M phosphate buffer pH 7.4. The sampling times were 5, 10, 15, 30, and 60 min. Liquid chromatography mass spectrometry (LC-MS) was used as a tool to determine amount of piperine. Different piperine release profiles were achieved and it was found that the reported method in this article was suitable for dissolution study only in capsule and tablet preparations.

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How to Cite
1.
Vutthipong A, Saingam W, Panrat T, Charoonratana T. DISSOLUTION PROFILE OF A TRADITIONAL THAI ANTIHYPERTENSIVE HERBAL RECIPE IN VARIOUS PREPARATIONS . Interprof J Health Sci [Internet]. 2023 Oct. 5 [cited 2024 Dec. 22];12(2):20-4. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/99
Issue
Vol. 12 No. 2 (2014): July - December
Section
Research Articles
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