https://li05.tci-thaijo.org/index.php/IJHS <p>ISSN (print): 2672-9628, ISSN (online): 2672-9423</p> <p>Interprofessional Journal of Health Sciences (Interprof. J. Health Sci. or IJHS), formerly Bulletin of Health, Science and Technology (BHST; ISSN: 0858-7531), is a multidisciplinary international scholarly journal for the publication of current knowledge and advances in health sciences with the online submission and review systems.</p> College of Pharmacy, Rangsit University en-US Interprofessional Journal of Health Sciences 2672-9628 <p><em>Journal of TCI is licensed under a Creative Commons </em><a href="https://creativecommons.org/licenses/by-nc-nd/4.0/"><em>Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)</em></a><em> licence, unless otherwise stated. Please read our Policies page for more information.</em></p> https://li05.tci-thaijo.org/index.php/IJHS/article/view/785 <p>Passion fruit (<em>Passiflora edulis f. flavicarpa</em> O. Deg.) peel is a sustainable phenolic source with potential for use as nutraceuticals and functional foods. This study optimized microwave-assisted extraction (MAE) via response surface methodology. A central composite design was used to evaluate the effects of the ethanol concentration (54.89–80.11%), microwave power (364.78–785.22 W), and irradiation time (1.64–8.36 min) on the total phenolic content (TPC). The optimized conditions—67% ethanol, 700 W, and 5.8 min—yielded 12.52 ± 0.27 mg gallic acid equivalents (GAE)/g dry basis, which was ~60% higher than that of conventional reflux extraction (7.80 ± 0.20 mg GAE/g) and nearly triple that of hot water extraction (4.50 ± 0.30 mg GAE/g). This work highlights MAE as a rapid, scalable, and environmentally sustainable strategy for valorizing agro-industrial byproducts. These findings provide a platform for future compound-level profiling, antioxidant activity validation, and pilot-scale processing to support the circular economy and nutraceutical innovation.</p> Bancha Yingngam Rojjares Netthong Jeerisuda Khumsikiew Nipaporn Muangchan Copyright (c) 2025 Interprofessional Journal of Health Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 2025-10-06 2025-10-06 23 2 0785