FT-IR STUDY BETWEEN PROPRANOLOL HYDROCHLORIDE AND PHARMACEUTICALLY ACCEPTABLE EXCIPIENTS IN PHYSICAL MIXTURE

Abstract

Propranolol hydrochloride (propranolol HCl) is a nonselective β-adrenergic blocking agent widely used for hypertension, angina pectoris, and many other cardiovascular disorders treatment. Fourier transform infrared spectroscopy (FT-IR) is a simple, rapid, and inexpensive method that was used to predict the drug-excipients interactions. Base on their frequent use in preformulation six pharmaceutically acceptable excipients: lactose, magnesium stearate, talcum, corn starch, microcrystalline cellulose pH 102 (avicel^® pH 102), and sodium starch glycolate (explotab^®) were mixed with propranolol HCl using simple physical technique in an agate mortar with pestle for approximately 5 min. The mixture samples were prepared by mixing propranolol HCl and each pharmaceutically acceptable excipients in a ratio of 1:1, 1:2, and 1:3 w/w. The FT-IR spectra showed the main peaks of propranolol HCl at 3270-3209, 2962-2715, 1250, and 802 cm^-1 were secondary of hydroxyl group, secondary of amine group, aryl alkyl ether, and substituted naphthalene, respectively. Propranolol HCl and pharmaceutically acceptable excipients had not been interacting in their physical mixtures. The increasing of amount ratio of pharmaceutically acceptable excipients obviously increased the intensity of main peak of each pharmaceutically acceptable excipients around 1600-1000 cm^-1.