DEVELOPMENT OF GAMMA ORYZANOL-LOADED NANOSTRUCTURED LIPID CARRIERS BY USING GLYCERYL STEARATE BLENDED PEG-100 STEARATE AS SOLID LIPID AND COLD PRESSED RICE BRAN OIL AS LIQUID LIPID
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Abstract
In this study, ɤ-oryzanol-loaded nanostructured lipid carriers (NLCs) were developed by using Tego® Care 165 (glyceryl stearate combined PEG-100 stearate, 50:50 (w/w)) as solid lipid and cold pressed rice bran oil as liquid lipid. They were varied by a ratio of solid lipid to liquid lipid and the amount of total lipids. The results showed instability in all formulations, except ɤ-NLC1 and ɤ-NLC9. The particle sizes of ɤ-NLC1 and ɤ-NLC9 showed smaller than 200 nm and polydispersity index values were less than 0.2. Zeta potential values were higher than -20 mV. Both formulations showed higher entrapment efficiency than 99%. Increasing the content of lipid showed precipitation from excess lipid. The mixed of three nonionic surfactants could stabilize formulations better than the mixed of two nonionic surfactants. Interestingly, particle sizes of NLCs reduced when the amount of nonionic surfactant increased. In summary, ɤ-NLC9 showed good physicochemical properties and promising stable formulation. Moreover, Tego® Care 165 and cold pressed rice bran oil are able to use solid lipid and liquid lipid for ɤ-oryzanol encapsulation.
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