PHYSICAL AND CHEMICAL PROPERTIES OF KHAMIN CHAN TABLETS: DIRECT COMPRESSION VS WET GRANULATION METHOD

Main Article Content

Worawan Saingam
Chaowalit Monton
Jirapornchai Suksaeree
Laksana Charoenchai
Thanapat Songsak
Sureewan Duangjit

Abstract

The objective of the present study was to formulation and evaluation physical and chemical properties of Khamin chan tablets. Khamin Chan (Curcuma longa Linn) has been used for Thai traditional medicine. It has therapeutic properties and can be used as stomachic and carminative. Khamin Chan, commonly use in capsule formulation. Khamin Chan tablets were prepared by direct compression and wet granulation method. The prepared powders and granules were evaluated such as angle of repose, bulk density, tapped density, compressibility index and hausner’s ratio. Khamin chan tablets were evaluated for weight variation, thickness, hardness, friability, disintegration and compared curcuminoid content from each method. As a results, the contents of curcuminoids from tablet which prepared by direct compression method and wet granulation method were 6.10 and 6.25 %w/w, respectively. Wet granulation method overcomes the problems associated with moisture in excipients and can be develop to industrial scale.

Article Details

How to Cite
1.
Saingam W, Monton C, Suksaeree J, Charoenchai L, Songsak T, Duangjit S. PHYSICAL AND CHEMICAL PROPERTIES OF KHAMIN CHAN TABLETS: DIRECT COMPRESSION VS WET GRANULATION METHOD. Interprof J Health Sci [Internet]. 2023 Oct. 5 [cited 2024 Dec. 6];13(2):56-62. Available from: https://li05.tci-thaijo.org/index.php/IJHS/article/view/121
Section
Research Articles

References

Abas F, Lajis NH, Shaari K, Israf DA, Stanslas J, Yusuf UK, Raof SM. 2005. Alabdane diterpene glucoside from the rhizomes of Curcuma mangga. J Nat Prod 68: 1090–1093.

Almedia LP, Cherubino APF, Alves RJ, Dufosse L, Gloria MBA. 2005. Separation and determination of the physico-chemical characteristics of curcumin, demethoxycurcumin and bisdemethoxycurcumin. Food Res Int. 38: 1039-1044.

Department of Medical Sciences, Ministry of Public Health. 1995. Khamin Chan.Thai Herbal Pharmacopoeia. Vol1. Bangkok : Prachachon; pp. 38-44.

Department of Medical Sciences, Ministry of Public Health. 2004. Khamin Chan capsules. Bangkok : Prachachon; pp. 31-32.

Siddiqui. 2015. Evaluation of thermo sensitivity of curcumin and quantification of ferulic acid and vanillin as degradation products by a validated HPTLC method. Pak. J. Pharm. Sci., Vol.28, No.1(Suppl), pp.299-305.

The United State Pharmacopeial Convention. 2009. The United State Pharmacopeia 33/The National Formulary 28. Maryland: United Book Press.